Try to keep your hand fairly flat relative to the surface as you execute mouse and gesture commands. With the large MultiTouch devices you can rest your whole hand on the surface while executing mouse, gesture, or typing. Keep your fingers in a natural posture - as if your hand was resting on your desk. All gestures should start from a relaxed posture. If your fingers are tightly bunched up you are not relaxing. When pointing try to use different finger pairs. You can even use your knuckles